THERAPY

Mavenclad

Cladribine

Coverage

Protocols

Before Initiation of Therapy :

  • CBC,CD4,CD8,creatinine, liver enzymes,Sodium, Potassium,bilirubin,urinalysis, TSH , JCV index
  •  HBsAg, anti-HBc, anti-HBs, Hepatits C, HIV, VZV serology
  • Vaccination status verified and updated if necessary
  • Pneumococcus and Haemophilus influenza type B vaccines
  • Need to wait 6 weeks after vaccination before starting medication
  • Recent cerebral MRI (<3 months)

Monitoring During Therapy :

  • Month 3,6,10 post cycle CBC,CD4,CD8,creatinine, liver enzymes,Sodium, Potassium,bilirubin,urinalysis, TSH

Lymphocyte≥1.0 before retreating

  • Annual cerebral MRI

Discontinue Therapy :

  • The half-life MMF, the active metabolite of DMF is 1 hour
  • The time for lymphocyte recovery is however several months

Product Monograph

Specific Concerns